2011 Vol. 17 Nr 3 - TIDNINGEN

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Kohan DE Endothelin-1 and hypertension: from bench to bedside. Curr Hypertens Rep 2008; 10:65-9. Kohan DE, Cleland JG, Rubin LJ, Theodorescu D, Barton M. Clinical trials with endothelin receptor antagonists: what went wrong and where can Endothelin-1 (ET-1) is an extremely potent vasoconstrictor peptide originally isolated from endothelial cells. Its synthesis, mainly regulated at the gene transcription level, involves processing 1997-02-22 2003-01-01 However, the control experiments using a pure endothelin‐independent vasodilator, i.e. nitroprusside show that the effect of nitroprusside on angiotensin II and noradrenaline‐induced vasoconstriction is much weaker when compared with the effect of the ET A ‐receptor antagonist BQ‐123, although nitroprusside when given alone exerts a marked vasodilation. endothelin on the renal microvasculature, and update recent findings on endothelin in the regulation of renal hemodynamics. Semin Nephrol 35:145-155 C 2015 Elsevier Inc. Endothelin-1, but not angiotensin II, induces afferent arteriolar myosin diphosphorylation as a potential contributor to prolonged vasoconstriction Kosuke Takeya1,2,3, Xuemei Wang2, Iris Kathol1,2, Kathy Loutzenhiser2, Rodger Loutzenhiser2 and Michael P. Walsh1 Blood striction mediated by endothelin ET~ receptors which may flow, systemic arterial pressure, heart rate, and pressure be opposed by an endothelin ET B receptor-mediated NO and d P / d t from the left ventricle were simultaneously release in dogs (Rigel and Lappe, 1993), and can produce recorded on a Grass model 7 polygraph.

Endothelin vasoconstriction

Endothelin type A receptors potentiate the vasoconstriction accompanying angiotensin II infusion or blockade of NOS. Endothelin is released by hypoxia, specific agonists such as angiotensin II, salt loading, and cytokines. Nonspecific blockade of endothelin receptors lowers BP in models of volume-expanded hypertension. Se hela listan på cvphysiology.com Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. The process is the opposite of vasodilation, the widening of blood vessels. The process is particularly important in controlling hemorrhage and reducing acute blood loss.

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In view of this profile of biologic action, it seemed plausible that endothelin could be involved in the development of the functional vascular disorder in scleroderma. Endothelins are 21- amino acid vasoconstricting peptides produced primarily in the endothelium having a key role in vascular homeostasis. Endothelins are implicated in vascular diseases of several organ systems, including the heart, lungs, kidneys, and brain.

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Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner Br J Pharmacol. 2020 Nov 12. doi: 10.1111/bph.15324.

We investigated the effect of endothelin on the renal microvasculature, and update recent findings on endothelin in the regulation of renal hemodynamics. Semin Nephrol 35:145-155 C 2015 Elsevier Inc. First, endothelin-dependent vasoconstriction is maximal at 34 μU/ml of insulin , but blocking endothelin receptors does not reveal insulin-induced dilatation at that concentration . Second, maximal NO-dependent vasodilatation occurs at a concentration of insulin of 3.4 mU/ml ( Fig. 2 ), but NOS inhibition does not reveal insulin-induced vasoconstriction at that concentration ( Fig. 3 ). Se hela listan på de.wikipedia.org However, the control experiments using a pure endothelin‐independent vasodilator, i.e.
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3,85,86 ET-1 is produced by endothelial cells in response to stimuli, including VEGF, and its secretion is inhibited by NO, PGI 2, ANP, and epidermal growth factor (EGF). 85,87,88 ET-1 mediates its effects through ET A R and ET B R, both of which are G-protein–coupled receptors.

Several factors increase ET-1 re Endothelins (EDNs) are a peptide family consisting of three different members (EDN1, EDN2, and EDN3) and sarafotoxins, which were originally defined by their vasoconstrictive actions.458 From: Knobil and Neill's Physiology of Reproduction (Fourth Edition), 2015 Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction 1. The experimental model using periods of ventilation with a gas mixture containing 10% oxygen in the anesthetized pig was found to induce HPV that was reproducible and … 1998-09-01 2021-03-01 Although endothelin-3 caused significantly less forearm vasoconstriction than endothelin-1 at low doses, vasoconstriction was similar to the two isopeptides at the highest dose (60 pmol/min). Endothelin-3 caused transient forearm vasodilatation at this dose, whereas endothelin-1 showed only a nonsignificant trend toward causing early vasodilatation.
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vasoconstriction — Svenska översättning - TechDico

Endothelin-1 is a potent, 21-amino acid vasoconstrictor peptide produced by Endothelin (ET) potent vasoconstrictor. Endothelial dysfunc7on may contribute to atherosclerosis and primary hypertension. Regleringssystem, hur många och On the other hand, immunoreactivity to the vasoconstrictor, endothelin, has been demonstrated throughout the endothelial cell layer of human coronary arteries Neuropeptide Y treatment induced retinal vasoconstriction and causes Enhanced Endothelin-1 Mediated Vasoconstriction of the Ophthalmic Artery May and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition.

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Endothelin-Receptor Blockade in Coronary Heart Disease - ICH GCP

Second, maximal NO-dependent vasodilatation occurs at a concentration of insulin of 3.4 mU/ml ( Fig. 2 ), but NOS inhibition does not reveal insulin-induced vasoconstriction at that concentration ( Fig. 3 ). Se hela listan på de.wikipedia.org However, the control experiments using a pure endothelin‐independent vasodilator, i.e.

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The effect of organ culture on endothelial dilatory endothelin ETB receptors is not known.

(a) The time courses of 0.1nmol/l Ang II– and ET-1–induced vasoconstriction are shown as mean values±s.e.m. (n¼5 for Ang II and n¼8 for ET-1), with the thin lines depicting the s.e.m.