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Statin pleiotropy is an important concept. In cell culture and animal studies, these effects alter the expression of endothelial nitric oxide synthase, the stability of atherosclerotic plaques, the production of proinflammatory cytokines and reactive oxygen species, the reactivity of platelets, and the development of cardiac hypertrophy and fibrosis. Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins. Pleiotropic effects are most commonly noticed in conjunction with genetic disorders, since a mutation on a single gene may result in multiple problems affecting growth and development, i.e., height, weight, skeletal development.

Pleiotropic effects

Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability). Pleiotropic effects of IL-8 on leukocytes have also been delineated in part by the use of antisense approaches. An IL-8 antisense oligonucleotide was found to specifically block the production of mono-cyte-derived angiogenic activity (Koch et al., 1992). Specific Effects Dementia Protection. Statins might help protect the brain from dementia.

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Maybe you missed chemistry at high school. Check out the site at www.profmontage.com.au Table 1. Pleiotropic effects of modified citrus pectin.

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Most biomedical reports of MCP focus specifically on its antagonism of galectin-3 (Gal-3). Located in the nucleus, cytoplasm, outer cell surface, and extracellular space, Gal-3 is a member of a β-galactoside-binding lectin family [ 49 ]. The pleiotropic effects of vitamin D and associated mechanisms are summarized in Table 1. In addition, the paracrine and autocrine effects of vitamin D have a protective role in many diseases.

Thus, a new mutation in the gene will affect all the phenotypes/traits 28 maj 2013 — In this study, three pig lines were used for the estimation of pleiotropic effect of the 1.94 Mbp region on SSC6: sow line 1 (~1450 animals); sow Pleiotropic Effects of GIP on Islet Function Involve Osteopontin.
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The pleiotropic effect is produced by a gene owing to a cascade (succession) of reactions during some metabolic pathway which is influenced by the original gene product and contributes to different phenotypic effects. Pleiotropic effects stem from both normal and mutated genes, but those caused by mutations are often more noticeable and easier to study. Pleiotropy is actually more common than its opposite, since in a complex organism, a protein from a single gene is likely to be expressed in more than one tissue, and the cascade of problems caused by a mutation is likely to lead to numerous complications Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models.

The rate-limiting enzyme in cholesterol biosynthesis in the liver is HMG-CoA reductase. 2014-04-08 · 3. Pleiotropic effects of statins.
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: producing more than one effect especially : having multiple phenotypic expressions a pleiotropic gene. Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins.

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Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Antagonistic pleiotropy is a theory proposed to explain how senescence, or biological aging, can be attributed to natural selection of certain pleiotropic alleles. In antagonistic pleiotropy, an allele that has a negative impact on an organism can be favored by natural selection if the allele also produces advantageous effects. Pleiotropic effects of medicines are generally beneficial. For instance, aspirin was originally used as a pain reliever and was later found to have the pleiotropic effect of lowering the risk of heart attack. Statin drugs have pleiotropic effects, which is one reason the medical community is so enthusiastic about them.

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The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. 2014-04-08 Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Moeller BJ(1), Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Author information: (1)Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. 2020-06-06 PLEIOTROPIC EFFECTS OF STATINS Dr.RENJU.S.RAVI MD 2. Cholesterol Cholesterol is an essential component of cell membranes and is the immediate precursor of steroid hormones and bile acids.  The rate-limiting enzyme in cholesterol biosynthesis in the liver is HMG-CoA reductase. 3.

High cholesterol is a risk factor for Arthritis Risk. Statins may also forestall development of the inflammatory disease rheumatoid arthritis. The The Lungs, The Eyes, and More. Statins are are also Se hela listan på academic.oup.com Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Moeller BJ(1), Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Author information: (1)Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. Comment in Cancer Cell.